The effect catabolite repression on a known secondary netabolite streptonycete

The possible involvement of carbon catabolite repression in control of synthesis of the polyether antibiotic M139603 was examined by culturing the producing organism S. Longisooroflavus in a variety of media containing a range of different carbon sources at different concentrations. From the results it has been tentatively concluded that carbon catabolite repression is not mediated by any of the carbon sources tested.